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While our efforts to define the endogenous ligand for NHR-49 were unsuccessful, mutating the ligand-binding pocket might allow us to determine the role of ligand binding in the transcriptional activity of NHR-49

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Radiotherapy can induce ferroptosis in the specified cancers through several pathways as following

In this context, its important to highlight the emerging role of membrane contact sites (MCS) in lipid transfer

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In Type 2 diabetes, glutathione supplementation aids in overcoming insulin resistance, reducing excessive insulin secretion-induced inflammation and relieving oxidative stress