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doi:10.2174/1389200003339171

If youre definitely not pregnant, here are 11 other reasons for a late period: Contraceptives Perimenopause Weight changes Hormonal imbalances Stress Chronic illness Breastfeeding Medications Endometriosis Ovarian cysts Alcohol and tobacco use 1

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The nuclear factor-kappa B (NFB) pathway associated cytokine release is inhibited, hence weakening the signal transduction by IL-1 and nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining-3 (NLRP3) inflammasome (Jo et al., 2016)