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In addition, with the recognition of various modes of cell death, the original necrosis or oncotic necrosis [79] was challenged to be apoptosis [14, 15], necroptosis [16, 17], and lately ferroptosis [18, 19] and even pyroptosis [20, 21]

In RBCs obtained from donors with non-hemolytic G6PD deficiency, whose RBCs have naturally aberrant flux through the pentose phosphate pathway at baseline, storage results in higher basal levels of glycolysis and ATP, despite increased oxidant stress

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Conjugated metabolites often have higher clearance than the parent drug, due in part to active excretion into urine and/or bile

Anti-nausea protocols (ondansetron 4mg as needed, small frequent meals, ginger supplementation) are effective adjuncts but don't address the receptor-level cause

Summary Keywords atherosclerosis, intraplaque hemorrhage, red blood cell lysis, hemoglobin oxidation, haptoglobin, hemopexin, heme-oxygenase, ferritin Citation Jeney V, Balla G and Balla J (2014) Red blood cell, hemoglobin and heme in the progression of atherosclerosis