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c-MET has also been shown by multiple studies to interact directly with the epidermal growth factor receptor (EGFR), allowing activation of c-MET after stimulation of cells with the EGFR ligands EGF or transforming growth factor (TGF-) [Jo et al

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Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH biosynthetic enzyme glutamate cysteine ligase (GCL)

Note that there is some evidence that PPS has lower efficacy in patients with Hunner lesions