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Int J Mol Sci 25:13086
"Folate and cobalamin in psychiatric illness"

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These intermediates are stabilized through H-bonds between their ribosyl 2-, 3- OH groups and the catalytic residue Glu226, a residue required for the NADase and cyclase activity of the enzyme [38-40, 58-60]
While generally safe, common B12 side effects include diarrhea and swelling at the injection site