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In the hyperglycemic state, AR depletes NADPH while increasing the accumulation of F6P, so there is a close influence between several glucose metabolic pathways

Furthermore, using transmission electron microscopy, we observed a characteristic set of changes in the mitochondria after APR-246 treatment, beginning with organelle condensation and disrupted cristae architecture, followed by gross swelling, loss of outer membrane integrity and eventual rupture (Supplementary Fig

Whole-genome analysis of sporadic amyotrophic lateral sclerosis

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This lack of standardization complicates the interpretation and comparison of results

Statements Author contributions YZ: Writingreview and editing, Writingoriginal draft