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SARS-CoV-2 ORF6 protein has also been shown to dysregulate redox homeostasis by decreasing Nrf2 expression, which can enhance viral replication 69

Research indicates that this complex can influence gene expression related to collagen production, extracellular matrix remodeling, and angiogenesis-associated signaling

In MASLD patients, immune responses against lipid peroxidation products may serve as important indicators of progression to advanced stages such as fibrosis

Devigili, G
GCs aid in BBB maintenance by enhancing the expression of TJs and AJs that strengthen the barrier [146]

Targeting antioxidants to mitochondria by conjugation to lipophilic cations
