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[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Velma V, Vutukuru SS, Tchounwou PB
Research use differs from medical use because a laboratory or preclinical study does not establish an approved human treatment
[PubMed 3402178] 1269
There is a need for extensive and rigorous studies to discover agents that can prevent cancer cells from evading the immune system
Moreover, increased expression of TET enzymes, coupled with decreased DNA methyltransferase (DNMT) activity, has been shown to result in the hypomethylation of other immune-related genes such as CTLA-4, further enhancing the suppressive function of Tregs in the tumor microenvironment and promoting tumor progression (Sasidharan Nair et al., 2018
Attenuation of Peripheral Serotonin Inhibits Tumor Growth and Enhances Immune Checkpoint Blockade Therapy in Murine Tumor Models
