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SIRT3, SIRT4, and SIRT5 are mitochondrial, SIRT2 is cytoplasmic whereas SIRT6, SIRT7 and SIRT1 are mainly nuclear (2)

Exercise modalities range widely across investigations, including concurrent training in postmenopausal women (Samadpour Masouleh et al., 2021), and multicomponent protocols in sarcopenic obesity (Ortiz et al., 2025)

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[DOI] [PubMed] [Google Scholar] 111.Riederer P, Monoranu C, Strobel S, Iordache T, Sian-Hulsmann J

These modifications not only hinder their microcirculatory movement but also function as molecular signals that facilitate their identification and removal by the reticuloendothelial system