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In T2DM, elevated LC3-II and p62 levels suggest that autophagic flux is active but may be dysfunctional due to inefficient degradation of the autophagosomes

Various stress response elements such as defense and stress element (TC-rich repeats), drought-inducer element (MBS), low-temperature response element (LTR), hypoxia inducible element (GC-motif) and anaerobic inducible element (ARE) were also detected, which is consistent with the function of the GST gene involved in stress regulation

In rats induced by advanced glycation end products (AGEs), GA downregulated expressions of MMP-2, MMP-9, and TGF-, thereby inhibiting extracellular matrix (ECM) remodeling and calcification and protecting vascular elasticity

This distinguishes it from GLP-1 agonists like semaglutide, which produce greater weight loss but carry a risk of muscle wasting

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