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Subjects were treated with open-label VYVANSE for at least 26 weeks prior to being assessed for entry into the randomized withdrawal period

Vyvanse is a prodrug (lisdexamfetamine) that the body converts to dextroamphetamine, which gives a slower, smoother onset and a steady effect

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doi:10.4103/2230-8210.179997

Brain energy metabolizing enzymes in Alzheimer's disease: alpha-ketoglutarate dehydrogenase complex and cytochrome oxidase Ann N Y Acad Sci 1997
