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At his worst, he was taking 14-days worth of Vicodin each day in order to achieve the same effect he originally had with 2 tablets, which contributed to his streak of 297 consecutive games played

A key to recovery after acetaminophen-induced liver injury is the onset of regeneration and replacement of necrotic hepatocytes [70], which is critically dependent on mitochondrial biogenesis [71]

GSH export from cultured astrocytes can also be stimulated by exposure to various substances without a preliminary increase in GSH content

In other words, the preclinical signal appears against a backdrop of controlled energy intake and activity, not as a standalone effect that overrides diet