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doi: 10.1016/0304-3940(94)90933-4 16 BarakatW.SafwetN.El-MaraghyN

Meanwhile, the NE released by the renal sympathetic efferent fibers directly acts on the 1 receptor of parapylebular cells, stimulating the massive secretion of renin through the Gs/cAMP/PKA signaling cascade, thereby initiating and amplifying the RAAS effect (254)

Cortisol is a secondary responder whereas norepinephrine and epinephrine are the primary responders that initiate the physiological changes, which kick the body into action when under stress

1 Despite advancements in chemotherapy, radiotherapy, immunotherapy, and targeted therapy, among all the possible reasons causing failure of anti-cancer treatments, development of therapeutic resistance accounts for up to 90% of cancer-associated deaths
