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After 41 h, we collected the secretomes and added to recipient SKOV3 cells (Fig

ROS alter conformation of mitochondrial pores to enhance the release of pro-apoptotic proteins (for example cytochrome c) and facilitate activity of MAPKs as well as transcription factors required for expression of both pro- and anti-apoptotic genes (Ji 2007

Additionally, oral theaflavin can improve the cognitive behavior of LPS-induced neuroinflammation by inhibiting the activation of M1-type microglia (Yue et al., 2014)

Thus, this molecule can enter the brain tissue and be shown to reduce the cognitive and motor deficits by enhancing neurogenesis

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Similarly, Th2 cells, which are responsible for promoting humoral immunity and antibody production, are disrupted in ME/CFS [55]