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Disrupting the p53/MDM2 interaction using molecules like ISA27 and nutlin-3a, or employing p53-binding circular RNAs (e.g., CDR1as), can effectively reinstate p53 activity and trigger apoptosis in undifferentiated GBM cells, thereby impeding tumor progression (Esemen et al., 2022)

3.1.2 Prebiotics and probiotics Oral prebiotics or probiotics reduce the production of metabolites by changing the composition of the gut microbiota

[53] Effect of some physical properties such as viscosity and dielectric constant on the stability of ascorbic acid in emulsions has also been investigated