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Several ARIs have successfully passed through phase I and II clinical trials but failed in phase III trials due to toxic side effects

The 2.5th and 97.5th percentiles of the distributions used in the outer loop of the simulation were used as minimum and maximum values, whereas patient-level variables varied by shifting distributions to the left and right by 20% of the mean values

doi: 10.1007/s00384-019-03484-y

This study suggested the extent of the angiogenic potential of the peptide is apparently very high as it appeared to extend not only on local wounds and ligaments but also on GI wounds and bone healing

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