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Drug Metabolism and pharmacokinetics of antisense oligonucleotide therapeutics: typical profiles, evaluation approaches, and points to consider compared with small molecule drugs

Lewerenz J, Klein M, Methner A

The metabolism of GSH conjugates to mercapturic acid begins either in the biliary tree, intestine or kidney, but the formation of the N-acetylcysteine conjugate usually occurs in the kidney (DeLeve and Kaplowitz, 1990)
Under oxidative stress, NRF2 escapes KEAP1-mediated degradation [56], translocates to the nucleus, and activates antioxidant genes including HO-1 and NQO1

But with the exception of GHK-Cu, none of these peptides have actually landed in Category 1, and none currently appear on any FDA 503A drug substance nomination list

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