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Interestingly, no tolerance for locomotor effects or anxiolysis appears in ARM-390-treated animals underlying the fact that biased agonist could be used at the behavioral level

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In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]

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