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Mutator mice harbor a homozygous D257A substitution in the catalytic PolgA subunit that renders the polymerase proofreading deficient, leading to the progressive accumulation of mtDNA mutations and deletions and premature aging 55,56

References ONeil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, et al

Nat Commun (2020) 11(1):404

Low glutathione levels have been observed in the brains of Parkinson's disease patients

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doi: 10.1038/s41416-018-0314-4 80 MadalaS.MacDougallK.SurapaneniB