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NAD+ supplementation (NAD+, NMN, NR) increases the supply of NAD+ precursors from outside the cell

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SS-31 has anti-apoptotic properties, meaning it can inhibit programmed cell death

S., De Simone, C

Specifically, NAD+ treatment inhibited the aberrant serine-specific phosphorylation of key BER enzymes, AP endonuclease (APE) and DNA polymerase- (-pol), which are typically inactivated during ischemic conditions