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Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

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In addition, pharmacological intervention with SAHA also restored the histone H3 acetylation level, reversed pathological form of synaptic plasticity, and abrogated the epileptic phenotype in the TSC2 +/ mice showing the neurological manifestations including seizures, autism and cognitive deficits [138]

PINK1 is cleaved by mitochondrial processing peptidase and the presenilin-associated rhomboid-like protease and is finally completely degraded by an MG132-sensitive protease (Greene et al., 2012)