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10.1126/science.278.5338.680 Science 13 EscotX.MirandaM.MenoyoS.Rodrguez-PorrataB.Carmona-GuterrezD.JungwirthH.et al (2012)

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Isosteric replacement of the pyrazolopyrimidinone core with an imidazotriazinone scaffold led to the discovery of vardenafil

Pereira AAL, De Mendonga Rego FJ, Morris VK, Overman MJ, Eng C, Garrett CR, Ferrarotto R, Lee MS, Jiang Z, Hoff PM, Vauthey J, Vilar Sanchez E, Maru DM, Kopetz S

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BPC-157 FDA Approval Status: Is It Approved for Human Use