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4.2 Cytotoxicity As shown in Table 2, studies in the literature in the last two decades have found that compounds extracted from coral have good cytotoxicity, particularly diterpenes, sesquiterpenes, sterols, and a small number of alkaloids, prostaglandins, and esters as active substances that also have some biological activity
Details are described below, with some technical advancements that decrease the frameshift mutation rate and thus render the method suitable for mutagenizing larger genes

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S.LacyP.et al (2008)
