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Risks of Improper IGF-1 LR3 Dosing Because IGF-1 stimulates growth pathways, excessive or unsupervised dosing may increase risks, including: Hypoglycemia (low blood sugar) Edema Joint discomfort Nerve compression symptoms Potential overstimulation of mitogenic pathways IGF-1 signaling is also involved in cellular proliferation

BMC Biol 23:325

Also noticed an old wrist injury feels better

doi:10.33549/physiolres.935209 Muir CA, Wittert GA, Handelsman DJ