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For experiments involving QCHS treatment, mice were randomly divided into 5 groups (n = 8): control group (Ctrl), model group (DSS), low-dose QCHS group (QCHS-L), medium-dose QCHS group (QCHS-M), and high-dose QCHS group (QCHS-H)

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Cysteine supplementation likely increases flux through the neural cysteine catabolism enzyme mercaptopyruvate sulfurtransferase (MPST) to increase the generation of H 2 S, although MPST shows low expression in mouse neurons (Supplementary Table 1)