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The upregulation of the SLC7A11/GSH/GPX4 axis, a key ferroptosis defense system, is a significant evasion mechanism evolved by tumor cells

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It was suggested that PX-478 lowers HIF-1 levels by affecting multiple levels in the HIF-1 pathway: (1) inhibition of HIF-1 deubiquitination via p53 and pVHL independent mechanism, resulting in increased levels of polyubiquitinated HIF-1

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MengQLiYJiTChaoYLiJFuYet alEstrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor alpha-mediated autophagy

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