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In total, 17% of patients experienced adverse drug reactions, again mostly fever, headache, pain, back pain, and nausea, though 5% had persistent pain and allodynia lasting greater than 2 weeks [165]

Alpha lipoic acid may improve the quality of life for individuals with neuropathy

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Within the hepatic environment, TMA is subjected to oxidation by flavin-containing monooxygenases (FMO), resulting in the conversion of TMA to TMAO, the fully oxidized derivative of the compound ( Figure 2 One mechanism by which the body maintains TMAO homeostasis is through excretion, the kidney is the prominent organ to eliminate TMAO