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It appears that GHK stimulates wound healing through a variety of mechanisms

Many peptides break down completely in the acidic stomach environment, rendering them ineffective when taken orally

Further, short half life of GHK-Cu wherein 50 % is eliminated in less than 2 hrs makes the situation extremely challenging

Cortisol is known to increase leptin production 60 and high circulating leptin concentrations are seen in patients with active Cushing syndrome, which in turn decrease during remission

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Among the trials that have been finished is the use of DFO in PD (Phase II), which appeared to reduce nigral iron on MRI but had no effect on the Unified PD Rating Scale (Martin-Bastida et al., 2017)