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GutDerived ShortChain Fatty Acids Bridge Cardiac and Systemic Metabolism and Immunity in Heart Failure. Journal of Nutritional Biochemistry 120: 109370
Factors that may contribute include: Separation of abdominal muscles Skin laxity following pregnancy Scar tissue formation Changes in fat distribution This area can be resistant to diet and exercise, which often leads individuals to consider surgical options like abdominoplasty

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As expected, 9 of the top 15 genes most highly upregulated were HSP genes

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