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Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against -amyloid toxicity

1 When IGF-1 binds to IGF-1R, the tyrosine kinase activates the phosphoinositide 3-kinase (PI3K)-AKT pathway and many integral proteins involved in cellular metabolism, apoptosis, cell adhesion, and angiogenesis are regulated within this pathway

FIGURE 3 FIGURE 4 Interestingly, the affinity between the ETGE motif and the Keap1 DC domain is much higher than that between the DLG motif and the Keap1 DC domain (Tong et al., 2006)

Toxicol Appl Pharmacol 152:366375 Wood TC, Salavagionne OE, Mukherjee B et al (2006) Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies

2015:en20151741

Maintenance is physiologically easier than reconstruction