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Preclinical data presented in a conference abstract demonstrated AG-946's ability to normalize levels of glycolytic intermediates, decrease 2,3-DPG levels, and increase hemoglobin levels in a Townes HbSS mouse model, although it did not significantly affect ATP levels or degree of RBC sickling

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Details about global DNA methylation analysis methods are beyond the scope of the current review

PMID: 11092245

But the gap between preclinical animal data and confirmed human clinical outcomes is still wide

Long-term maintenance is often necessary to preserve the effects of glutathione injections, particularly for skin brightening goals