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Description
Here we report the crystal structures of the regulatory sulphenic and irreversible sulphinic and sulphonic acids of protein tyrosine phosphatase 1B (PTP1B), an important enzyme in the negative regulation of the insulin receptor 7,8 and a therapeutic target in type II diabetes and obesity 9

Roberts et al., 2011)

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Mainly because pH is not the same in all parts of our body
