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Could my position change as research evolves

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ABHD5 ligands that release ABHD5 from PLIN1 or PLIN5 independent of PKA activation, led to the discovery of long-chain acyl-CoA (LC-CoA) as an endogenous allosteric regulator of ABHD5 that promotes the interaction with PLIN1/5 (48)

The molecule has been studied in animal models of adipose-tissue metabolism, with published preclinical work examining its effects on NAD+ pool dynamics and on the methyl-donor balance NNMT regulates

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