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Description
Igf-1 null mice that reach adulthood have relative body weights dropping to 32% compared to that of normal animals ( igf-1 null mice and the reported human case of igf-1 mutation, a number of non-skeletal phenotypic differences do exist

There was no significant worsening of renal function of any study participant

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This approach allows for early safety evaluation before broader cohort exposure

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SURMOUNT-1 results (72 weeks, adults with obesity): 5 mg dose: approximately 15% body weight loss 10 mg dose: 19.5% body weight loss 15 mg dose: 22.5% body weight loss Placebo: 3.1% body weight loss At the 15 mg maximum dose, the average participant lost about 52 pounds over 72 weeks
