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This effect is highly similar to the ScGrx7 mutants K105A and K105Y (Figs 2 and 3)

Nature 588 , 327330 (2020)

While cyanocobalamin is a common synthetic form used in basic supplements, natural coenzyme forms like methylcobalamin and adenosylcobalamin are often preferred because the body can utilize them immediately for cellular energy and neurological support
We think he needs a higher dose

This study, the CARES trial, looked at 5000 patients, all of whom had some cardiovascular disease history, either heart attack, stroke, min-stroke or need for urgent heart surgery for coronary disease

Think of it as neural training for resilience
