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Supplementary Data 1 (download XLSX Numerical source data for Supplementary Fig

This method is also frequently applied to evaluate NO scavenging capacity in vitro

Specifically, we analyzed affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and the hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete or incomplete infarcts (10% of area affected)

Specifically, interventions aimed at improving the metabolic ratio between 2-hydroxyestrone (2-OHE1) and 16-alpha-hydroxyestrone (16-OHE1)whether through dietary modifications, pharmacological agents, or targeted enzymatic inhibition of CYP1A1 and CYP1B1may further reduce hyperpigmentation by promoting the production of less biologically active estrogen metabolites [119,120,121]