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The mechanisms by which macrophages resist ferroptosis help provide us with new insights into the mechanisms of ferroptosis in the endometriosis model

doi: 10.1038/s41467-020-15068-4 102 SpadoniIZagatoEBertocchiAPaolinelliRHotEDi SabatinoAet al

This, in turn, results in the activation of the unfolded protein response (UPR), the endoplasmic reticulum overload response, and the caspase-12-mediated apoptosis pathway

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Furthermore, mTOR inhibitors potently promote T-cell unresponsiveness, i.e., the diminished or loss of T-cell responsiveness to antigenic stimuli, in both in vitro and in vivo experiments (226, 227), which provides strong support for the reduction of rejection in contexts requiring immunosuppression, such as after organ transplantation

Final reassurance and common-sense rules Remember: most people experience only short-lived soreness or a small bruise