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Another stress factor, pain due to cold, produces increased permeability to albumin, although it is only found in women [70]

US Department of Agriculture and US Department of Health and Human Services

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As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]

Damaged tissue gets cleared away

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.McCord JM, Fridovich I