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Laboratory studies demonstrated: Enhanced fatty acid oxidation in treated animal models Increased plasma glycerol release (an established index of active lipolysis) Elevated mitochondrial fatty acid oxidation capacity Both energy expenditure and fat oxidation increases even without classical -AR pathways The peptide appears to modulate metabolic flexibility in adipocytes

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Bull Exp Biol Med 2001;131:28592

Furthermore, this analysis found no clear advantages of nutritional interventions, noting that only a limited number of such trials were assessed [145]

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