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Angew Chem Int Ed Engl.51(22):5308-32

363 Gpx4-deficient activated Tregs are susceptible to ferroptosis and exhibit enhanced production of the proinflammatory cytokine IL-1, leading to a promotion of T helper cell 17 (Th17) responses

Ascorbic acid and glutathione in this cycle can maintain protein stability and cell membrane integrity, and together with APX and GR, constitute the ascorbate-glutathione cycle (Miao et al., 2021)

Later work confirmed LL-37 acts as a self-antigen that T-cells in many psoriasis patients directly attack, tying it deeper into the disease mechanism (Lande et al., Nat Commun, 2014)

Clin Otolaryngol Allied Sci
