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Although transplantation is a potential option, it carries risks because of the multi-organ involvement of the disease [5,13,43]
1 2 3 "World Drug Report 2014" (PDF)
In a zebrafish model, compared with C3-carnitine, C18-carnitine and C18:1-carnitine can induce the inhibition of OXPHOS, interfere with the energy supply of cardiomyocytes, and lead to a significant impairment of cardiac systolic function, which manifests as a decreased heart rate and reduced shortening of the atrial and ventricular fractions [21]
therefore, in vitro assays serve as practical tools to screen multiple processing conditions (Ribas-Agust et al., 2018)
STEMI, ST-segment elevation myocardial infarction
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