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Remember these key points: Patient Selection is Paramount: The patient must have chronic low back pain for over six months, with documented failure of at least six months of conservative care, and confirmed Type 1 or Type 2 Modic changes on an MRI
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Cycle length: Research schedules commonly run multi-week cycles
Subsequent elevations in NAD+ levels activate sirtuin 1 (SIRT1), a cellular regulatory enzyme dependent on NAD+ availability

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