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The ability of either -glutamylcysteine or its cognate cofactor, GSH, to dispose H 2 O 2 in vitro was then assessed in the absence or presence of purified GPx1

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Other target organs included kidney (increased weight, glomerular and tubular epithelial swelling, pigmentation of tubular epithelial cells), nasal epithelium (glandularization of the respiratory epithelium, pigment deposition in and degeneration of olfactory epithelium), thyroid (follicular cell hyperplasia), thymus (involution) and pancreas (mononuclear cell infiltration), while lung pathology (emphysema, atelectasis and bronchiolization of alveolar cell walls) was reported in rabbits