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Description
In addition to the physiological functions of protein-bound lipoic acid, there is increasing scientific and medical interest in potential therapeutic uses of pharmacological doses of free (unbound) lipoic acid (3)
By mimicking the fat-metabolizing region of growth hormone, AOD-9604 signals the body to break down stored triglycerides into free fatty acids for energy [1, 2]
Additionally vascular dilation and leakage induced by BKN might aggravate hypovolemia in high flow POTS, e.g., POTS in MCAS
doi: 10.3791/1135 24 LuoT.FanT.LiuY.RothbartM.YuJ.ZhouS.et al
doi: 10.2337/db16-0153
On analyzing the interaction of the co-crystallized ligand (Flavin-Adenine Dinucleotide, FAD) with the protein, we identified that FAD forms hydrogen bonding with Glu50, Ala130, Ser51, Thr57, Lys66, Thr339, Asp331, Gly31 and Ser30
