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Additionally, this review of HUM Nutrition, like all health-related content on this website, was thoroughly vetted by one or more members of our Medical Review Board for accuracy

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The more reduced mitochondrial [NAD + ]/[NADH] during fasting and DR from increased neural fatty acid oxidation (low capacity in neurons) and ketone body oxidation may slow the mitochondrial malate dehydrogenase 2 (MDH2) enzyme of the MAS, inhibiting flux through the MAS leading to the more reduced cytoplasmic [NAD + ]/[NADH] observed in the brain of animals on the DR diet