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Reports have also indicated that long-term treatments involving cabozantinib induce less resistance and can improve the efficacy of gemcitabine and can overcome gemcitabine resistance in pancreatic cancer (Hage et al., 2013)

It has been hypothesized that the endocytosis of LPS by KC could induce upregulation of cytokine receptors, especially the TNF- receptor, which seems to be also involved in the increased ROS production (95)

Glutathione plays a major role in many chemical reactions in the body

In complex epigenetic networks, single-enzyme inhibition can produce unpredictable effects and readily trigger compensatory reprogramming, occasionally reinforcing resistant states [381]

Excessive circulating lipids cause neuroinflammation and oxidative damage, both associated with cognitive impairment