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Decreased nuclear -catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 conditional transgenic mice

Oxidative stress (OS) is considered to be involved in the development of many various diseases, e.g., cancer [29], diabetes [30], cardiovascular [21] or liver disorders [31], Alzheimers disease [32], psychological disturbances [33], pathological states affecting reproductive health [34,35,36] any many others

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Ostrom QT, Wright CH, Barnholtz-Sloan JS

The direction of effect is consistent

For example, intracellular pathogens are metabolically restricted through limited access to metal ions, vitamin cofactors, and amino acid pools [69]