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Genes with low confidence score or without any hit were analysed using a BLASTP reciprocal best hit approach [85] using the NCBI BLAST web interface ( The selected word size was three and low complexity regions were excluded

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A (eds) GeneReviews

SARS-CoV-2 infection can induce death or damage to brain endothelial cells through SARS-CoV-2 protease, which cleaves the Nf-B essential modulator (NEMO), leading to BBB disruption and subsequent neuroinflammation [102]

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It has also been used in the treatment of peripheral vascular disease and diabetic neuropathy, where it helps improve blood flow and reduce pain associated with these conditions