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In his words, if a cell is sick, intracellular calcium is elevated

Conflict of interest: S

inspired by nonribosomal peptide natural products, researchers are also developing peptides featuring N-amino (hydrazide) and N -hydroxy (hydroxamate) groups, characterized by NH 2 or OH substituents on the backbone amide

Pierce ECL (Thermo Fisher Scientific, MA, USA) or WesternSurePREMIUM (LI-COR Biosciences, Nebraska, USA) chemiluminescent substrates and a digital scanner (C-Digit Blot Scanner, LI-COR Biosciences, Nebraska, USA) were used to visualize protein expression

Given that glial and neuronal cells undergo aging-related changes, including SASP, alterations in extracellular matrix composition, mitochondrial DNA release, and activation of inflammatory signaling pathways, shifts in membrane or lipid environments may influence these processes by modulating LLPS and domain dynamics

Several pharmacological agents and natural compounds (e.g., rapamycin, losartan, sirolimus, and andrographolide) show efficacy in experimental CD models by modulating specific cell death pathways