inhibition of glutathione reductase Targeting Metabolism: Partner in Crime in Anticancer Therapy Recycling of Glutathione by Glutathione

10.1016/j.pbi.2006.07.005 Curr

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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by pyruvate dehydrogenase and therefore that TCA cycle flux is diminished (Gray et al., 2015

However, our results demonstrated that GSH overproduction confers SA accumulation and elevated resistance also to a virus pathogen, TMV

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However, it is not FDA-approved for human use and cannot legally be marketed as a drug, supplement, or for human consumption